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Design Reactions in Flow Chemistry

Published on December 12, 2023February 20th, 2024By

Vapourtec has launched a continuous stirred tank reactor (CSTR) designed for continuous process synthesis and works in conjunction with their existing, industry-leading flow chemistry systems. DesignEdge worked closely on the highly complex parts, additive manufacturing was incorporated due to the intricate geometries while maintaining optimal mechanical properties and chemical resistance.

The CSTR has been designed and developed in close liaison with leading flow chemists within industry and academia. Allowing for a cascade of up to eight reactors within an R-Series flow chemistry system that includes two R4 modules, Vapourtec’s CSTR is perfect for flow reactions involving solids and liquids. It operates at a pressure up to 5.0 bar with volume ranging from 5 ml to 40 ml per CSTR and can heat and cool the reactor in the range -10°C to +150°C. The easy to clean and assemble system delivers safety and precision with stirring speeds from 100rpm to 1200rpm and features a built-in burst disc as well as optional protective screens. There is also the option for a photo-chemical CSTR using LED light sources from 365nm to 700nm.

Dr. Manuel Nuño of Vapourtec explained: “CSTRs are commonly used within chemical synthesis however our approach has been to adapt that to flow chemistry and ensure it complements our two continuous process systems. A single CSTR can prove to be unsuitable as the residence time distribution (RTDs) exhibits significant variability. With an eight reactor cascade it is possible to approach the performance of tubular reactors allowing for the separation of reaction products from starting materials and offering tightly controlled RTDs. The stirring speeds and temperatures can also be set up in a fully bespoke way for each individual CSTR which helps to deliver greater control and accuracy across the entire system leading to more precise outcomes.”

Vapourtec flowchem systems have contributed towards the development of exciting new synthetic routes for important therapeutics including breast cancer drug Tamoxifen, Artemisinin for the treatment of malaria and peptide drugs focused on the treatment of type 2 diabetes.

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